- Title
- Curcumin alleviates postprandial glycaemic response in healthy subjects: A cross-over, randomized controlled study
- Creator
- Thota, Rohith N.; Dias, Cintia B.; Abbott, Kylie A.; Acharya, Shamasunder H.; Garg, Manohar L.
- Relation
- Scientific reports Vol. 8, Issue 1, no. 13679
- Publisher Link
- http://dx.doi.org/10.1038/s41598-018-32032-x
- Publisher
- Nature Publishing
- Resource Type
- journal article
- Date
- 2018
- Description
- In the current study, we aimed to evaluate the effects of a single dose of curcumin and/or fish oil on postprandial glycaemic parameters in healthy individuals. This was a randomised, placebo-controlled and crossover study. Sixteen (n=16) volunteers were randomised to receive placebo, curcumin (180mg) tablets, fish oil (1.2g long chain omega-3 polyunsaturated fatty acids) capsules and curcumin+fish oil prior to a standard meal on 4 test days separated by a week. Blood glucose, serum insulin and triglycerides were measured at intervals between 0-120min. Difference between the treatments was measured using two-way repeated measures analysis of variance and pair-wise comparisons using Wilcoxon signed-rank or paired t-test as appropriate. Postprandial glucose concentrations were significantly lower in the curcumin (60.6%, P=0.0007) and curcumin+fishoil group (51%, P=0.002) groups at 60min from baseline. Compared with placebo, area under the curve (AUC) for change in blood glucose concentration was reduced by curcumin (36%, P=0.003) and curcumin+fishoil (30%, 0.004), but not fish oil alone (p=0.105). Both curcumin (P=0.01) and curcumin+fishoil (P=0.03) treatments significantly lowered postprandial insulin (AUC) by 26% in comparison with placebo. Curcumin, but not fish oil, reduces postprandial glycaemic response and insulin demand for glucose control.
- Subject
- fish oil; metabolic diseases; metabolic regulation; postprandial blood glucose
- Identifier
- http://hdl.handle.net/1959.13/1412198
- Identifier
- uon:36438
- Identifier
- ISSN:2045-2322
- Rights
- CC-BY This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Language
- eng
- Full Text
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